Economic sanctions, a widely used tool in international diplomacy, significantly influence global dynamics, particularly in response to political and economic threats. In light of ongoing geopolitical shifts, these sanctions not only have notable economic and political effects on target countries but also present critical legal and jurisprudential challenges concerning state sovereignty and human rights. This paper offers a fresh analysis of the legal and jurisprudential underpinnings of economic sanctions in the context of these geopolitical changes, exploring the multifaceted nature of sanctions from both Islamic jurisprudential and international legal perspectives. The primary aim of this study is to evaluate the legitimacy of sanctions from both a legal and jurisprudential standpoint, considering the evolving geopolitical environment and recent advancements in international law. This research follows a descriptive-analytical methodology, utilizing a broad range of legal, jurisprudential, and international resources. The paper particularly emphasizes the impact of sanctions on human rights and the challenges of aligning Islamic jurisprudential principles with international legal frameworks governing sanctions. The research highlights key conflicts and challenges in reconciling legal and jurisprudential frameworks for sanctions, stressing the necessity to revisit international legal standards, especially in regard to human rights and the sovereignty of affected states in the face of geopolitical transformations. Ultimately, the paper proposes the creation of new legal frameworks that incorporate both geopolitical transformations and jurisprudential principles